系统介绍


FreezeScan是Gene&I联合国外厂商推出的进行条件性恐惧实验的分析系统。可以分析在一个固定的活动箱内任意角度的视频文件,它可以精确分析啮齿类动物恐惧行为的发生和结束。

FreezeScan不仅可以精确地监测动物恐惧行为,还可以在实验过程中以数字和图形的形式提供精确地动物瞬时活动度水平,使震惊反应研究成为可能。

除此之外,通过额外的实验硬件,还可以进行动物共情行为的研究




系统特点

 全功能条件性恐惧行为分析系统

 主控机可同时控制64个装置

 活动度测量可进行震惊反应研究

 高通量模式可同时进行4个活动箱内的实验

 实时分析功能和录像后分析功能

●  自动监测视频中视觉信号的开关(如LED灯)

●  可进行多种时间间隔设置

●  自动生成时间间隔数据

●  简易双击回放功能

Reference

I-Ting Judy Wang, Megan Allen, Darren Goffin, Xinjian Zhu, Andrew H. Fairless, Edward S. Brodkin, Steve J. Siegel, Eric D. Marsh, Julie A. (2012) Blendy, and ZhaolanZhou ,(2012) Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice, PNAS, Dec 2012; 109: 21516 – 21521.

Lin H-C, Gean P-W, Wang C-C, Chan Y-H, Chen PS (2013) The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat Autism Model. PLoS ONE 8(1): e55248. doi:10.1371/journal.pone.0055248.

Sotres-Bayon, Francisco; Sierra-Mercado, Demetrio; Pardilla-Delgado, Enmanuelle; Quirk, Gregory􀳦J. (2012) Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs, Neuron doi:10.1016/j.neuron.2012.09.028 (volume 76 issue 4 pp.804 - 812).

Kristen A. Rahn, Crystal C. Watkins, Jesse Alt, Rana Rais, MarigoStathis, Inna Grishkan, Ciprian M. Crainiceau, Martin G. Pomper, Camilo Rojas, Mikhail V. Pletnikov, Peter A. Calabresi, Jason Brandt, Peter B. Barker, Barbara S. Slusher, and Adam I. Kaplin, (2012) Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis, PNAS 2012; doi:10.1073/pnas.1209934109.

Pushpinder K. Multani, Rachel Hodge, Marcel A. Estévez, Ted Abel, Hank Kung, Mark Alter, Bethany Brookshire, Irwin Lucki, Aleksandra H. Nall, Konrad Talbot, Glenn A. Doyle, Falk W. Lohoff, (2012) VMAT1 Deletion Causes Neuronal Loss in the Hippocampus and Neurocognitive Deficits in Spatial Discrimination, Neuroscience Available online 28 November 2012.




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